Alone in the aging lab, graduate biochemistry student Kristen Scott makes a frantic phone call to researcher Holly Manning. Something terrible has happened, gasps Kristen, but before she can go into more detail, that something terrible arrives to silence the petite girl! The cause of Kristen's panic is a creature with the body of a human but the head and hands of a giant lizard! When Holly arrives in response to the call, she's shocked to find Kristen sitting bound and gagged in a chair - - a position she soon finds herself in after the Lizard Man overpowers her! Trussed up in their lab coats, silenced with cloths tied between their lips, Kristen and Holly writhe nervously as they contemplate the experimental disaster that's turned a man into a monster!